A national German network

The disease-oriented Competence Network Multiple Sclerosis (KKNMS) is made up of 14 member MS centers, in which 21 different projects are ongoing. In addition, the KKNMS includes study centers where patients are recruited and monitored. To get a better idea of how the network functions, we provide an interactive map:

Georg-August-Universität Göttingen

Universitätsmedizin
Abteilung Medizinische Informatik:

1.2 IT platform for the Competence Network Multiple Sclerosis (CoreUnitIT)
Co-PI: Dr. Karoline Buckow

Institut für Neuropathologie:

1.4 BrainBank
PI: Prof. Dr. Wolfgang Brück
Co-PI: Dr. Erik Bahn

Abteilung Neuroimmunologie:

5.1 Generation of tools to characterize CD4+ T cells in rat models for multiple sclerosis and neuromyelitis optica (CD4-MS&NMO)
PI: Prof. Dr. Alexander Flügel
Co-PI: Dr. Dmitri Lodygin

Heinrich-Heine-Universität Düsseldorf

Neurologische Klinik

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
PI: Prof. Dr. Orhan Aktas

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PIs Studienzentrum: Prof. Dr. Hans-Peter-Hartung und Prof. Dr. Orhan Aktas

Johannes-Gutenberg-Universität Mainz

Klinik für Neurologie

3.2 Brain network patterns as prognostic and therapy response markers in multiple sclerosis (MSNetworks)
PI: Prof. Dr. Frauke Zipp
Co-Pis: Prof. Dr. Sergiu Groppa, Dr. Felix Lüssi

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Frauke Zipp

Klinikum Augsburg

Neurologische Klinik und klinische Neurophysiologie

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
Assoziiertes Mitglied: Dr. Antonios Bayas

Ludwig-Maximilians-Universität München

Institut für Klinische Neuroimmunologie

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
Co-PI: Prof. Dr. Tania Kümpfel

3.4 B-cells and antibody profiles (BIginMS)
PI: Prof. Dr. Edgar Meinl
Co-PI: Prof. Dr. Reinhard Hohlfeld

5.5 Improved assessment of disease phenotypes in multiple sclerosis models (PhenoModel)
PI: Prof. Dr. Martin Kerschensteiner

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Reinhard Hohlfeld

Max-Planck-Institut für Biochemie

5.5 Improved assessment of disease phenotypes in multiple sclerosis models PhenoModel)
Co-PI: Dr. Gurumoorthy Krishnamoorthy

Max-Planck-Institut für Psychiatrie

1.5 Biostatistical support and data analysis (Biostat)
Co-PI: Prof. Dr. Bertram Müller-Myhsok

4.2 Genetic determinants of MRI changes in MS (Gene-MRI)
Co-PI: Prof. Dr. Bertram Müller-Myhsok

4.3 Genetic determinants of cerebrospinal fluid parameters in multiple sclerosis (Gene-CSF)
Co-PI: Prof. Dr. Bertram Müller-Myhsok

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. Frank Weber

Medizinische Hochschule Hannover

Neurologische Klinik

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
Co-PI: PD Dr. Corinna Trebst

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. Martin Stangel

Philipps-Universität Marburg

Central Information Office:

1.2 IT platform for the Competence Network Multiple Sclerosis (CoreUnitIT)
PI: Dr. Gisela Antony

2.1 Prospective cohort study in clinically isolated syndrome and early multiple sclerosis (KKNMS-Kohorte)
Co-PI: Dr. Gisela Antony

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
Co-PI: Dr. Gisela Antony

2.4 Extension and internationalization of REGIMS, an immune therapy register for the improvement of drug safety and treatment of patients with MS (REGIMS)
Co-PI: Dr. Gisela Antony

Universitätsklinikum Marburg, Klinik für Neurologie:

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: PD Dr. Björn Tackenberg

Ruhr-Universität Bochum

Neurologische Universitätsklinik:

2.1 Prospective cohort study in clinically isolated syndrome and early multiple sclerosis (KKNMS-Kohorte)
PI: Prof. Dr. Ralf Gold
Co-PI: Dr. Anke Salmen

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
Co-PIs: PD Dr. Kerstin Hellwig, Prof. Dr. Ingo Kleiter

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Ralf Gold

Institut für diagnostische und interventionelle Radiologie und Nuklearmedizin:

1.6 MRI Quality and Standards (MuSIQC)
PI: Prof. Dr. Carsten Lukas

4.2 Genetic determinants of MRI changes in MS (Gene-MRI)
Co-PI: Prof. Dr. Carsten Lukas

Technische Universität München

Klinikum rechts der Isar
Klinik und Poliklinik für Neurologie

1.1 Central Network Coordination (CoreOffice)
PI: Sandra Hanschke

1.3 Biomaterial Bank of the KKNMS (Biobank)
PI: Prof. Dr. med. Bernhard Hemmer

4.2 Genetic determinants of MRI changes in MS (Gene-MRI)
PI: Prof. Dr. Mark Mühlau

4.3 Genetic determinants of cerebrospinal fluid parameters in multiple sclerosis (Gene-CSF)
PI: Prof. Dr. Bernhard Hemmer
Co-PIs: Dr. Dorothea Buck, Dr. Markus Kowarik

5.2 Interplay of antigen specific T cells and B cells in mouse models of neuromyelitis optica (T-B in NMO)
PI: Prof. Dr. Thomas Korn

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Bernhard Hemmer

Universität Freiburg

Neurologische Universitätsklinik
Neuropathologie

5.4 Immune phenotyping of myeloid subsets during autoimmune inflammation (MonoMac)
PI: Prof. Dr. Marco Prinz

Universität Ulm

Neurologische Universitätsklinik

3.6 Predictive markers of imminent recurrence or rebound disease activity in MS patients switching immunotherapy (ReboundMS)
Co-PI: Prof. Dr. Hayrettin Tumani

4.3 Genetic determinants of cerebrospinal fluid parameters in multiple sclerosis (Gene-CSF)
Co-PI: Prof. Dr. Hayrettin Tumani

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Hayrettin Tumani

Universität Heidelberg

Neurologische Klinik
Sektion Molekulare Neuroimmunologie

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
Co-PI: Prof. Dr. Brigitte Wildemann

3.5 Signatures of immune reprogramming in anti-CD52 therapy of MS: markers for risk stratification and treatment response (ProgramMS)
Co-PI: Prof. Dr. Brigitte Wildemann

3.6 Predictive markers of imminent recurrence or rebound disease activity in MS patients switching immunotherapy (ReboundMS)
PI: Prof. Dr. Brigitte Wildemann
Co-PI: Dr. Jürgen Haas

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Brigitte Wildemann

Universität zu Lübeck

Universitätsklinikum Schleswig-Holstein – Campus Lübeck
Institut für Medizinische Biometrie und Statistik

1.5 Biostatistical support and data analysis (Biostat)
PI: Prof. Dr. Andreas Ziegler

2.1 Prospective cohort study in clinically isolated syndrome and early multiple sclerosis (KKNMS-Kohorte)
Co-PI: Prof. Dr. Andreas Ziegler

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
Co-PI: Prof. Dr. Andreas Ziegler

Universitätsklinikum Carl Gustav Carus an der TU Dresden

Klinik und Poliklinik für Neurologie

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. Tjalf Ziemssen

Universitätsklinikum Charité

Institut für Neuroimmunologie

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. Friedemann Paul

Universitätsklinikum Erlangen

Neurologische Klinik
Neuroimmunologie

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. Ralf Linker

Universitätsklinikum Hamburg-Eppendorf

Molekulare Neurobiologie Hamburg (ZMNH)
Institut für Neuroimmunologie und Multiple Sklerose (INIMS)

2.2 Comparing and Contrasting Multiple Sclerosis and Neuromyelitis optica Spectrum Disorders (NEMOS)
Co-PI: Dr. Jan-Patrick Stellmann

5.3 Modeling CD8+ T cell responses in multiple sclerosis (CD8Model)
PI: Prof. Dr. Manuel Friese

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Christoph Heesen

Universitätsklinikum Leipzig

Klinik und Poliklinik für Neurologie

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: PD Dr. Florian Then Bergh

Universitätsklinikum Rostock

Klinik für Neurologie und Poliklinik

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. Uwe Zettl

Universitätsklinikum Tübingen

Allgemeine Neurologie

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. Ulf Ziemann

Westfälische Wilhelms-Universität Münster

Universitätsklinikum – Department für Neurologie:

1.3 Biomaterial Bank of the KKNMS (Biobank)
Co-PI: Prof. Dr. Heinz Wiendl

3.1 Multi-parameter immune cell-profiling: identification of biosignatures to understand heterogeneity, prognosis and treatment response factors (ImmuneMS)
PI: Prof. Dr. Heinz Wiendl
Co-PIs: PD Dr. Luisa Klotz; Dr. Catharina Groß

3.5 Signatures of immune reprogramming in anti-CD52 therapy of MS: markers for risk stratification and treatment response (ProgramMS)
PI: Prof. Dr. Dr. Sven Meuth
Co-PIs: Prof. Dr. Heinz Wiendl, Dr. Tobias Ruck

3.6 Predictive markers of imminent recurrence or rebound disease activity in MS patients switching immunotherapy (ReboundMS)
Co-PIs: Prof. Dr. Heinz Wiendl, Prof. Dr. Dr. Sven Meuth

Studienzentrum der KKNMS-Kohorte (Projekt 2.1)
PI Studienzentrum: Prof. Dr. med. Heinz Wiendl

Institut für Epidemiologie und Sozialmedizin:

2.4 Extension and internationalization of REGIMS, an immune therapy register for the improvement of drug safety and treatment of patients with MS (REGIMS)
PI: Prof. Dr. Klaus Berger

Membership in the KKNMS is only open to applicants whose projects have been approved by the German Federal Ministry for Education and Research (BMBF). However, it is possible for researchers in associated projects to access samples and data of the KKNMS. It is also possible to become a supporting member of the non-profit organization „KKNMS e.V.“.