Towards a better understanding of multiple sclerosis: linking insights gained from animal models to humans

UNDERSTAND^MS is concerned with the cause (pathogenesis) and development of multiple sclerosis. The researchers in this network search for clues in both patients as well as animal models which allow for conclusions on the individual pathogenetic factors and manifestations of MS. The goal is to transfer new research findings in animal models as directly as possible to humans, and vice versa. These findings, in combination with innovative imaging methods which visualize lesions in the central nervous system, will allow researchers to understand the disease forms more clearly. Furthermore, these research approaches will contribute to the optimization of diagnostics and the development of more individualized patient therapy regimens.

Four alliances, one goal

The research network is comprised of four alliances which focus on the following topics:

• Alliance I: Various aspects of the pathogenesis as well as the different disease courses in MS will be simulated in rodents to identify the causes and pathogenetic mechanisms of MS.

• Alliance II: The researchers attempt to shed light on which immunregulatory factors are disturbed in MS and how these can be positively influenced by treatment measures. The importance of tolerogenic mechanisms will be studied, also as to their potential for developing new therapies.

• Alliance III: Investigators examine the roll of B cells and antibodies in multiple sclerosis and use their findings to improve diagnostics or treatment conditions.

• Alliance IV: The researchers are working on the optimization of current MRT imaging methods in order to recognize and evaluate early damage to and regeneration processes in the central nervous system.

Core units provide support for the network

Two core units belong to UNDERSTAND^MS and support its work:

• Cellular biobanking: A biobank will be established at the University Clinic Muenster to collect cellular biomaterial. In addition, peripheral blood mononuclear cells (PBMCs) will be isolated.

• Animal models: The members of this work group will support the research network by developing novel mouse models for simulating human MS.

The expertise of the core units “CNS pathology” and “IT” are focussed in the like-named task forces of the KKNMS.

The research network coordinator is Prof. Dr. Heinz Wiendl (University of Muenster) and his deputy coordinator is Prof. Dr. Wolfgang Brück (University Medical Center Goettingen).